Sudanese Journal of Ophthalmology

ORIGINAL ARTICLE
Year
: 2018  |  Volume : 10  |  Issue : 1  |  Page : 14--17

Effect of subconjunctival antivascular endothelial growth factor on corneal neovascularization after penetrating keratoplasty


Deeksha Lochab, Renu Dhasmana, Neeti Gupta 
 Department of Ophthalmology, Himalayan Institute of Medical Sciences, Swami Rama Himalayan University, Dehradun, Uttarakhand, India

Correspondence Address:
Renu Dhasmana
Department of Ophthalmology, Swami Rama Himalayan University, Dehradun - 248 140, Uttarakhand
India

Purpose: To evaluate the effect of subconjunctival anti-VEGF on corneal neovascularisation post penetrating keratoplasty. Methods: A total of 31 eyes of 31 patients with corneal neovascularisation post penetrating keratoplasty were subjected to 2.5 mg/0.1 ml of subconjunctival bevacizumab in each quadrant of neovascularisation. We evaluated the regression of corneal neovascularisation after subconjunctival bevacizumab at 1 week, 4 weeks and 6 weeks and the incidence of complications and subjective complaints related to the treatment was also noted. Results: This was an experimental study, conducted from September 2015 to September 2016. A total of 31 patients with corneal neovascularisation post penetrating keratoplasty were included in the study, out of which 27(87.1%) were males and 4(12.9%) were females. 90.3% of patients had neovascularisation in all 4 quadrants, 6.5% had neovascularisation in 2 quadrants and only 3.2% had neovascularisation in only 1 quadrant. All patients who were subjected to subconjunctival bevcizumab, the regression of neovascularisation at 1 week, 4 weeks and 6 weeks was noted and there was a significant decrease in neovascularisation in central segments 1.97 ± 3.72 as compared to pre 5.13 ±7.12(p=0.001) and also in peripheral segments at 6 weeks 29.90 ± 15.73 as compared to pre bevacizumab 44.32 ± 17.97(p<0.001). Conclusion: The use of subconjunctival bevacizumab seems to be an effective and safe method in the treatment of corneal neovascularisation.


How to cite this article:
Lochab D, Dhasmana R, Gupta N. Effect of subconjunctival antivascular endothelial growth factor on corneal neovascularization after penetrating keratoplasty.Sudanese J Ophthalmol 2018;10:14-17


How to cite this URL:
Lochab D, Dhasmana R, Gupta N. Effect of subconjunctival antivascular endothelial growth factor on corneal neovascularization after penetrating keratoplasty. Sudanese J Ophthalmol [serial online] 2018 [cited 2019 Jun 19 ];10:14-17
Available from: http://www.sjopthal.net/article.asp?issn=1858-540X;year=2018;volume=10;issue=1;spage=14;epage=17;aulast=Lochab;type=0